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Article

Haplotype-based score test for linkage in nuclear families.

BMC bioinformatics - 1 Aug 2007

Nam Chung Mo, Kang Dae Ryong, Kim Jinheum

Abstract excerpt

BACKGROUND: To look for genetic linkage between angiotensin-I converting enzyme(ACE) gene and hypertension in a Korean adolescent cohort, we developed a powerful test using the covariances between marginal differences and their variances in a transmission/non-transmission table. RESULTS: We estimated haplotype frequencies using the parental and affected offspring's genotypes and then constructed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17672913
DOI: 10.1186/1471-2105-8-277
PMCID: PMC2140270

Genes

ACE

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