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Article

Apoptotic changes precede mitochondrial dysfunction in red cell-type pyruvate kinase mutant mouse erythroleukemia cell lines.

Japanese journal of cancer research : Gann - 1 Feb 1999

Aisaki K, Kanno H, Oyaizu N, Hara Y, Miwa S, Ikawa Y

Abstract excerpt

Two erythroleukemia cell lines have been established from the splenic lesions of red blood cell-type pyruvate kinase (R-PK) activity-deficient mice of CBA/N origin infected with a polycythemic strain of Friend leukemia virus complex (FVp). Ten to 30% of the cells of these cell lines undergo apoptotic changes in routine passage, as shown by nuclear fragmentation, DNA laddering, DNA content (propidium iodide (PI)...

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Identifiers

PMID: 10189887
DOI: 10.1111/j.1349-7006.1999.tb00730.x
PMCID: PMC5926040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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