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Article

Conservation of NADPH utilization by chorismate synthase and its implications for the evolution of the shikimate pathway.

Molecular microbiology - 1 Sept 2007

Ehammer Heidemarie, Rauch Gernot, Prem Anna, Kappes Barbara, Macheroux Peter

Abstract excerpt

The shikimate pathway is essential for the biosynthesis of aromatic compounds. The seventh and last step is catalysed by chorismate synthase, which has an absolute requirement for reduced FMN in its active site. There are two classes of this enzyme, which are distinguished according to the origin of the reduced cofactor. Monofunctional chorismate synthases sequester it from the cellular environment whereas...

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PMID: 17662045
DOI: 10.1111/j.1365-2958.2007.05861.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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