Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations associated with retinopathies alter mitogen-activated protein kinase-induced phosphorylation of neural retina leucine-zipper.

Molecular vision - 12 Jul 2007

Swain Prabodha, Kumar Sandeep, Patel Dharmesh, Richong Sushmita, Oberoi Pranav, Ghosh Madhumita, Swaroop Anand

Abstract excerpt

PURPOSE: Neural retina leucine-zipper (NRL), a member of the basic motif leucine zipper family of transcription factors, is preferentially expressed in rod photoreceptors of the mammalian retina. Mutations in NRL are associated with retinopathies; many of these are suggested to change phosphorylation status and alter NRL-mediated transactivation of rhodopsin promoter. The purpose of this study was to identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Leucine Zippers
Share to MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinases

Share to Retina

Share to Retinal Diseases

Share to Retinitis Pigmentosa

Share to Rhodopsin

Source

Open in PubMed Open full text

Identifiers

PMID: 17653056
PMCID: PMC2779144

Genes

NRL
CRX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations associated with retinopathies alter mitogen-activated protein kinase-induced phosphorylation of neural retina leucine-zipper.PMID 17653056Read ↗

Retinopathy mutations in the bZIP protein NRL alter phosphorylation and transcriptional activity.Semantic proximity Read ↗

Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retinaSemantic proximity Read ↗

Distinct gene expression profiles and reduced JNK signaling in retinitis pigmentosa caused by RP1 mutations.Semantic proximity Read ↗

Recessive NRL mutations in patients with clumped pigmentary retinal degeneration and relative preservation of blue cone function.Semantic proximity Read ↗

MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation.Semantic proximity Read ↗

A comprehensive analysis of sequence variants and putative disease-causing mutations in photoreceptor-specific nuclear receptor NR2E3.Semantic proximity Read ↗

Retinal dysplasia in mice lacking p56lck.Semantic proximity Read ↗

Activated MAPK/ERK kinase (MEK-1) induces transdifferentiation of pigmented epithelium into neural retina.Semantic proximity Read ↗

Characterization of MPP4, a gene highly expressed in photoreceptor cells, and mutation analysis in retinitis pigmentosa.Semantic proximity Read ↗

Identification of variants and dual promoters of murine serine/threonine kinase KKIAMRE.Semantic proximity Read ↗

Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations.Semantic proximity Read ↗

Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.