Article
Pitfalls in LightCycler diagnosis of the single-nucleotide polymorphism 13.9 kb upstream of the lactase gene that is associated with adult-type hypolactasia.
Clinica chimica acta; international journal of clinical chemistry - 1 Sept 2007
Weiskirchen Ralf, Tag Carmen G, Mengsteab Senait, Gressner Axel M, Ingram Catherine J E, Swallow Dallas M
Abstract excerpt
BACKGROUND: Patients presenting with symptoms of lactose intolerance are in some centres routinely tested for a single-nucleotide polymorphism C-13910T, which is located upstream of the lactase gene (LCT) and is tightly associated with genetically determined lactase persistence/non-persistence. Typing of this polymorphism enables differential diagnosis for genetic versus secondary causes of lactose intolerance....
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