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Article

Evaluation of a novel reverse-hybridization StripAssay for typing DNA variants useful in diagnosis of adult-type hypolactasia.

Clinica chimica acta; international journal of clinical chemistry - 1 Jun 2008

Tag Carmen G, Oberkanins Christian, Kriegshäuser Gernot, Ingram Catherine J E, Swallow Dallas M, Gressner Axel M, Ledochowski Maximilian, Weiskirchen Ralf

Abstract excerpt

BACKGROUND: Adult-type hypolactasia is a genetically determined inability to digest lactose after weaning. Two single-nucleotide polymorphisms (C-13910T, G-22018A) located upstream of the lactase gene (LCT) within the gene MCM6 are associated with the lactase persistence/non-persistence trait in patients of European descent. Therefore, the genotyping of these SNPs has been established as a diagnostic tool for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18396155
DOI: 10.1016/j.cca.2008.03.006

Genes

LCT
MCM6

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