Article
Iron absorption by Belgrade rat pups during lactation.
American journal of physiology. Gastrointestinal and liver physiology - 1 Sept 2007
Thompson Khristy, Molina Ramon M, Donaghey Thomas, Brain Joseph D, Wessling-Resnick Marianne
Abstract excerpt
Divalent metal transporter-1 (DMT1) mediates dietary nonheme iron absorption. Belgrade (b) rats have defective iron metabolism due to a mutation in the DMT1 gene. To examine the role of DMT1 in neonatal iron assimilation, b/b and b/+ pups were cross-fostered to F344 Fischer dams injected with (59)FeCl(3) twice weekly during lactation. Tissue distribution of the radioisotope in the pups was determined at weaning...
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