Article
Somatic cell hybridization of Roberts syndrome and normal lymphoblasts resulting in correction of both the cytogenetic and mutagen hypersensitivity cellular phenotypes.
Somatic cell and molecular genetics - 1 Sept 1991
Allingham-Hawkins D J, Tomkins D J
Abstract excerpt
Roberts syndrome (RS) is a rare recessive condition of limb deformities, growth retardation, and developmental delay. Cultured cells from approximately half of RS patients exhibit a "puffing" of the constitutive heterochromatin and a hypersensitivity to mitomycin C (MMC). Patients exhibiting these cellular phenomena are designated RS+. Somatic cell hybridization with normal cells has been shown to correct the...
Topics
- Abnormalities, Multiple
- Child, Preschool
- Dose-Response Relationship, Drug
- Female
- Genes, Recessive
- Growth Disorders
- Humans
- Hybrid Cells
- Lymphocytes
- Male
- Mitomycin