Article
Chromosomal breakage, endomitosis, endoreduplication, and hypersensitivity toward radiomimetric and alkylating agents: a possible new autosomal recessive mutation in a girl with craniosynostosis and microcephaly.
Human genetics - 1 Oct 1993
Tommerup N, Mortensen E, Nielsen M H, Wegner R D, Schindler D, Mikkelsen M
Abstract excerpt
A high frequency of spontaneous chromosomal breakage, endomitosis, endoreduplication and hypersensitivity toward both the alkylating agent Trenimon and the radiomimetric drug bleomycin was observed in phytohemagglutinin-stimulated peripheral lymphocytes from a girl with craniosynostosis, microcep...
Topics
- Adult
- Bleomycin
- Chromosome Aberrations
- Consanguinity
- Craniosynostoses
- DNA
- Drug Hypersensitivity
- Female
- Humans
- Infant
- Lymphocytes
- Male
- Microcephaly
- Mitosis
- Multigene Family
- Mutation
- Triaziquone