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Article

A novel tripartite motif involved in aquaporin topogenesis, monomer folding and tetramerization.

Nature structural & molecular biology - 1 Aug 2007

Buck Teresa M, Wagner Justin, Grund Steven, Skach William R

Abstract excerpt

Aquaporin (AQP) folding in the endoplasmic reticulum is characterized by two distinct pathways of membrane insertion that arise from divergent residues within the second transmembrane segment. We now show that in AQP1 these residues (Asn49 and Lys51) interact with Asp185 at the C terminus of TM5...

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Source

Identifiers

PMID: 17632520
DOI: 10.1038/nsmb1275

Genes

AQP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17632520-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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