Article
Rearrangements of NTRK1 oncogene in papillary thyroid carcinoma.
Neuro endocrinology letters - 1 Jun 2007
Brzeziańska Ewa, Pastuszak-Lewandoska Dorota, Lewiński Andrzej
Abstract excerpt
Papillary thyroid carcinoma (PTC) represents an example of tumour with high incidence of oncogenic sequences, such as RET/PTC and Trk. Both of them arise from the fusion of 3' terminal sequences of TK domain of RET or NTRK1 gene, respectively, with 5' terminal sequences of their activating genes. In case of NTRK1 oncogene, several rearrangement types are observed, characteristic for PTC: Trk (TMP3), Trk-T1,...
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