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Article

TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation.

PLoS pathogens - 1 May 2015

Greenfeld Hannah, Takasaki Kaoru, Walsh Michael J, Ersing Ina, Bernhardt Katharina, Ma Yijie, Fu Bishi, Ashbaugh Camille W, Cabo Jackson, Mollo Sarah B, Zhou Hufeng, Li Shitao, Gewurz Benjamin E

Abstract excerpt

The Epstein-Barr virus (EBV) encoded oncoprotein Latent Membrane Protein 1 (LMP1) signals through two C-terminal tail domains to drive cell growth, survival and transformation. The LMP1 membrane-proximal TES1/CTAR1 domain recruits TRAFs to activate MAP kinase, non-canonical and canonical NF-kB pathways, and is critical for EBV-mediated B-cell transformation. TRAF1 is amongst the most highly TES1-induced target...

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Share to Cell Transformation, Viral
Share to Epstein-Barr Virus Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 4, Human

Share to TNF Receptor-Associated Factor 1

Share to TNF Receptor-Associated Factor 2

Share to Ubiquitin-Protein Ligase Complexes

Share to Ubiquitination

Share to Viral Matrix Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25996949
DOI: 10.1371/journal.ppat.1004890
PMCID: PMC4440769

Genes

TRAF1
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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