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Article

Persistent and stable gene expression by a cytoplasmic RNA replicon based on a noncytopathic variant Sendai virus.

The Journal of biological chemistry - 14 Sept 2007

Nishimura Ken, Segawa Hiroaki, Goto Takahiro, Morishita Mariko, Masago Akinori, Takahashi Hitoshi, Ohmiya Yoshihiro, Sakaguchi Takemasa, Asada Masahiro, Imamura Toru, Shimotono Kunitada, Takayama Kozo, Yoshida Tetsuya, Nakanishi Mahito

Abstract excerpt

Persistent and stable expression of foreign genes has been achieved in mammalian cells by integrating the genes into the host chromosomes. However, this approach has several shortcomings in practical applications. For example, large scale production of protein pharmaceutics frequently requires laborious amplification of the inserted genes to optimize the gene expression. The random chromosomal insertion of...

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PMID: 17623660
DOI: 10.1074/jbc.M702028200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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