Article
Pharmacogenomics and serotonergic agents: research observations and potential clinical practice implications.
Neurogastroenterology and motility - 1 Aug 2007
Camilleri M
Abstract excerpt
Pharmacogenomics of serotonin are potentially relevant in research and clinical practice. There are few proven examples of the importance of pharmacogenetics of serotonin-modifying agents used in functional gastrointestinal or motility disorders. Drug metabolism is dependent on function of the cytochrome P450 enzymes, such as 2D6 and 3A4. Genetic variations in transporters and translation mechanisms have been...
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