Article
Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jul 2007
van der Burg Sjoerd H, Piersma Sytse J, de Jong Annemieke, van der Hulst Jeanette M, Kwappenberg Kitty M C, van den Hende Muriel, Welters Marij J P, Van Rood Jon J, Fleuren Gert Jan, Melief Cornelis J M, Kenter Gemma G, Offringa Rienk
Abstract excerpt
Because of their important role in the maintenance of self-tolerance, CD4(+) regulatory T cells prevent autoimmune diseases but also curtail the efficacy of T cell immune responses against cancers. We now show that this suppressive action of CD4(+) regulatory T cells is not limited to cancers displaying tumor-associated self antigens, such as melanomas, but also extends to human papillomavirus (HPV)-positive...
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