Article
Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.
American journal of physiology. Cell physiology - 1 Nov 2007
Ono Hiraku, Sakoda Hideyuki, Fujishiro Midori, Anai Motonobu, Kushiyama Akifumi, Fukushima Yasushi, Katagiri Hideki, Ogihara Takehide, Oka Yoshitomo, Kamata Hideaki, Horike Nanao, Uchijima Yasunobu, Kurihara Hiroki, Asano Tomoichiro
Abstract excerpt
Carboxy-terminal modulator protein (CTMP) was identified as binding to the carboxy terminus of Akt and inhibiting the phosphorylation and activation of Akt. In contrast to a previous study, we found CTMP overexpression to significantly enhance Akt phosphorylation at both Thr(308) and Ser(473) as well as the kinase activity of Akt, while phosphatidylinositol 3-kinase (PI3-kinase) activity was unaffected....
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