Article
Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers.
Lung cancer (Amsterdam, Netherlands) - 1 Oct 2007
Costa Daniel B, Kobayashi Susumu, Tenen Daniel G, Huberman Mark S
Abstract excerpt
PURPOSE: Epidermal growth factor receptor (EGFR) mutations have been found in the majority of gefitinib-responsive non-small cell lung cancer (NSCLC) patients from retrospective studies. We sought to compile the available phase II and prospective trials of this EGFR tyrosine kinase inhibitor (TKI) to better understand the efficacy and safety of selecting patients to receive gefitinib based on their genotype....
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