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Article

Interindividual variability in the concentration-effect relationship of antilymphocyte globulins - a possible influence of FcgammaRIIIa genetic polymorphism.

British journal of clinical pharmacology - 1 Jan 2008

Ternant David, Büchler Matthias, Bénéton Maud, Alván Gunnar, Ohresser Marc, Touchard Guy, Hurault de Ligny Bruno, Toupance Olivier, Watier Hervé, Lebranchu Yvon, Paintaud Gilles

Abstract excerpt

AIMS: Polyclonal antilymphocyte globulins (ALGs) are currently used in transplantation, but the sources of interindividual variability of their effect are poorly understood. No pharmacokinetic-pharmacodynamic (PK-PD) study of ALG is available. Moreover, the genetic polymorphism of FcgammaRIIIa, a receptor for the Fc portion of immunoglobulins involved in antibody-dependent cellular cytotoxicity (ADCC), may...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17610526
DOI: 10.1111/j.1365-2125.2007.02967.x
PMCID: PMC2291273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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