Article
Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2005
Krajewska Maryla, Kim Hoguen, Kim Chul, Kang Haeyoun, Welsh Kate, Matsuzawa Shu-Ichi, Tsukamoto Michelle, Thomas Ronald G, Assa-Munt Nuria, Piao Zhe, Suzuki Koichi, Perucho Manuel, Krajewski Stan, Reed John C
Abstract excerpt
PURPOSE: Although most stage II colon cancers are potentially curable by surgery alone, approximately 20% of patients relapse, suggesting a need for establishing prognostic markers that can identify patients who may benefit from adjuvant chemotherapy. We tested the hypothesis that differences in expression of apoptosis-regulating proteins account for differences in clinical outcome among patients with early-stage...
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