Article
Radiogenomic analysis to identify imaging phenotypes associated with drug response gene expression programs in hepatocellular carcinoma.
Journal of vascular and interventional radiology : JVIR - 1 Jul 2007
Kuo Michael D, Gollub Jeremy, Sirlin Claude B, Ooi Clara, Chen Xin
Abstract excerpt
PURPOSE: To determine whether conventional contrast-enhanced computed tomography (CT) could be used to identify imaging phenotypes associated with a doxorubicin drug response gene expression program in hepatocellular carcinoma (HCC) by using an integrated imaging-genomic approach. MATERIALS AND METHODS: Thirty HCCs were analyzed and scored individually across six predefined imaging phenotypes. Unsupervised and...
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