Article
Determination of mutations of the 23S rRNA gene of Helicobacter pylori by allele specific primer-polymerase chain reaction method.
Journal of gastroenterology and hepatology - 1 Jul 2007
Nakamura Akiko, Furuta Takahisa, Shirai Naohito, Sugimoto Mitsushige, Kajimura Masayoshi, Soya Yoshihiro, Hishida Akira
Abstract excerpt
BACKGROUND AND AIMS: Susceptibility to clarithromycin of Helicobacter pylori (H. pylori) is caused by single nucleotide polymorphisms (SNPs) of the 23SrRNA gene. Allele specific primer-polymerase chain reaction (ASP-PCR) is one of the methods for determining SNPs, which can measure SNPs easily within a short period by PCR amplification alone without digestion with restriction enzymes. The aim of the present study...
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