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Article

Modified active site coordination in a clinical mutant of sulfite oxidase.

Journal of the American Chemical Society - 1 Aug 2007

Doonan Christian J, Wilson Heather L, Rajagopalan K V, Garrett Robert M, Bennett Brian, Prince Roger C, George Graham N

Abstract excerpt

The molybdenum site of the Arginine 160 --> Glutamine clinical mutant of the physiologically vital enzyme sulfite oxidase has been investigated by a combination of X-ray absorption spectroscopy and density functional theory calculations. We conclude that the mutant enzyme has a six-coordinate pseudo-octahedral active site with coordination of Glutamine Oepsilon to molybdenum. This contrasts with the wild-type...

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Identifiers

PMID: 17608478
DOI: 10.1021/ja071402a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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