High sensitivity of human centrin 2 toward radiolytical oxidation: C-terminal tyrosinyl residue as the main target.

doi:10.1016/j.freeradbiomed.2007.04.004

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High sensitivity of human centrin 2 toward radiolytical oxidation: C-terminal tyrosinyl residue as the main target.

Free radical biology & medicine - 15 Jul 2007

Blouquit Yves, Duchambon Patricia, Brun Emilie, Marco Sergio, Rusconi Filippo, Sicard-Roselli Cécile

Abstract excerpt

Centrins are calcium-binding proteins that play a significant role in the maintenance of the centrosomal organization, mainly in the continuity between centrosome and microtubular network. Recent data showed that centrosome duplication abnormalities, like overduplication for example, could be due to hydrogen peroxide, suggesting an important impact of oxidative stress. To challenge this hypothesis, we performed...

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High sensitivity of human centrin 2 toward radiolytical oxidation: C-terminal tyrosinyl residue as the main target.

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