Article
Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation.
Lung cancer (Amsterdam, Netherlands) - 1 Dec 2007
Morinaga Ryotaro, Okamoto Isamu, Furuta Kazuyuki, Kawano Yukiko, Sekijima Masaru, Dote Kensaku, Satou Takao, Nishio Kazuto, Fukuoka Masahiro, Nakagawa Kazuhiko
Abstract excerpt
We report a case of small cell lung cancer (SCLC) developing after prolonged treatment (more than 2 years) for primary adenocarcinoma of the lung, and we show that both the SCLC and non-small cell lung cancer (NSCLC) tissues obtained from the same site share the same deletion in exon 19 of EGFR. This case suggests that the activating EGFR mutations may confer the pathogenesis of a subset of SCLC.
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