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Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen

9 Oct 2017

Abstract excerpt

High-risk human papillomaviruses (HPVs) infect epithelial cells and are causally associated with cervical cancer, but HPV infection is not sufficient for carcinogenesis. Previously, we reported that estrogen signaling in the stromal tumor microenvironment is associated with cervical cancer maintenance and progression. We have now determined how HPV oncogenes and estrogen treatment affect genome-wide host gene...

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Share to Cervical Cancer and HPV Research
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PMID: 29073104
DOI: 10.1073/pnas.1712018114

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