Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human MUC4 mucin cDNA and its variants in pancreatic carcinoma.

Journal of biochemistry - 1 Aug 2000

Choudhury A, Moniaux N, Winpenny J P, Hollingsworth M A, Aubert J P, Batra S K

Abstract excerpt

The human MUC4 gene is not expressed in normal pancreas; however, its dysregulation results in high levels of expression in pancreatic tumors. To investigate the tumor-associated expression, MUC4 cDNA was cloned from a human pancreatic tumor cell line cDNA expression library using a polyclonal antibody raised against human deglycosylated mucin and RT-PCR. Pancreatic MUC4 cDNA shows differences in 12 amino acid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Blotting, Northern
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermal Growth Factor

Share to Mucins

Share to Pancreatic Neoplasms

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10920259
DOI: 10.1093/oxfordjournals.jbchem.a022746

Genes

MUC4
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human MUC4 mucin cDNA and its variants in pancreatic carcinoma.PMID 10920259Read ↗

Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins.Semantic proximity Read ↗

Cloning and sequencing of a human pancreatic tumor mucin cDNA.Semantic proximity Read ↗

Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cellsSemantic proximity Read ↗

MUCIN-4 (MUC4) is a novel tumor antigen in pancreatic cancer immunotherapy.Semantic proximity Read ↗

Structure, evolution, and biology of the MUC4 mucinSemantic proximity Read ↗

MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanismsSemantic proximity Read ↗

MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cellsSemantic proximity Read ↗

Integrative Analysis of MUC4 to Prognosis and Immune Infiltration in Pan-Cancer: Friend or Foe?Semantic proximity Read ↗

The role of the AMOP domain in MUC4/Y-promoted tumour angiogenesis and metastasis in pancreatic cancerSemantic proximity Read ↗

Generation and Characterization of Anti-MUC4 Monoclonal Antibodies Reactive with Normal and Cancer Cells in HumansSemantic proximity Read ↗

Expression of MUC1, MUC2, MUC3 and MUC4 mucin mrnas in human pancreatic and intestinal tumor cell linesSemantic proximity Read ↗

Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.