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Article

Muc4/MUC4 Functions and Regulation in Cancer

15 Dec 2009

Abstract excerpt

The membrane mucin MUC4 (human) is abundantly expressed in many epithelia, where it is proposed to play a protective role, and is overexpressed in some epithelial tumors. Studies on the rat homologue, Muc4, indicate that it acts through anti-adhesive or signaling mechanisms. In particular, Muc4/MUC4 can serve as a ligand/modulator of the receptor tyrosine kinase ErbB2, regulating its phosphorylation and the...

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Glycosylation and Glycoproteins Research
HER2/EGFR in Cancer Research
Monoclonal and Polyclonal Antibodies Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20001800
DOI: 10.2217/fon.09.125

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