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Article

Adoptively transferred human lung tumor specific cytotoxic T cells can control autologous tumor growth and shape tumor phenotype in a SCID mouse xenograft model.

Journal of translational medicine - 25 Jun 2007

Oflazoglu Ezogelin, Elliott Mark, Takita Hiroshi, Ferrone Soldano, Henderson Robert A, Repasky Elizabeth A

Abstract excerpt

BACKGROUND: The anti-tumor efficacy of human immune effector cells, such as cytolytic T lymphocytes (CTLs), has been difficult to study in lung cancer patients in the clinical setting. Improved experimental models for the study of lung tumor-immune cell interaction as well as for evaluating the efficacy of adoptive transfer of immune effector cells are needed. METHODS: To address questions related to the in vivo...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

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Share to Lymphocytes, Tumor-Infiltrating

Share to Mice, SCID

Share to T-Lymphocytes, Cytotoxic

Share to Xenograft Model Antitumor Assays

Source

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Identifiers

PMID: 17592641
DOI: 10.1186/1479-5876-5-29
PMCID: PMC1933531

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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