Tumor-reactive T-cells accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor.

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Article

Tumor-reactive T-cells accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor.

Cancer research - 15 Feb 1992

Yoshino I, Yano T, Murata M, Ishida T, Sugimachi K, Kimura G, Nomoto K

Abstract excerpt

The purpose of this study was to elucidate a possible immune response to tumor cells mediated by tumor-infiltrating lymphocytes (TIL) in lung cancer. In flow cytometry, the majority of T-cells of TIL were CD45RA-, CD45RO+, and CDw29high, and expressed HLA-DR. The expression of interleukin 2 recep...

Topics

Antigens, CD
CD4 Antigens
CD8 Antigens
Carcinoma
Cell Line
Cell Separation
Flow Cytometry
Fluorescein-5-isothiocyanate
HLA-DR Antigens
Humans
Interleukin-2
Lung
Lung Neoplasms
Lymphocyte Activation
Lymphocytes, Tumor-Infiltrating
Phenotype
Receptors, Interleukin-2
Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 1737336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1737336-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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