Paternal age and birth defects: how strong is the association

Abstract excerpt

Sir, Yang et al. (2006) examined the association of paternal age and birth defects, one of which was Down syndrome, using a cohort of over 5 million subjects. They adjusted for maternal age in 10-year age bands and reported that advanced paternal age was associated with increased risks of Down syndrome. This result is almost certainly subject to residual confounding by maternal age. Kazaura and Lie (2002)...

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