Article
A novel single nucleotide polymorphism, IVS2 -97A>T, in the prostaglandin F2alpha receptor gene was identified among the Malaysian patients with glaucoma.
The Kobe journal of medical sciences - 1 Jan 2007
Peng Hoh Boon, Zahary Mohd Nizam, Tajudin Liza Sharmini Ahmad, Lin Chieng Li, Teck Cheong Min, Sidek Mohamad Ros, Zulkifli Azman, Zilfalil Bin Alwi
Abstract excerpt
The Prostaglandin F2alpha (PGF2alpha) receptor gene has been found to play an important role in reducing the intraocular pressure of the glaucomatous patients. Variations of the PGF2alpha receptor gene may be responsible for the differences in the response to an antiglaucoma drug, Latanoprost. A combined method of denaturing High Performance Liquid Chromatography (dHPLC) and sequencing was applied to detection of...
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