Article
Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults.
Neurobiology of aging - 1 Apr 2012
Ponomareva Natalya V, Goltsov Andrey Y, Kunijeva Svetlana S, Scheglova Nadejda S, Malina Daria D, Mitrofanov Andrey A, Boikova Tatiana I, Rogaev Evgeny I
Abstract excerpt
The epsilon4 allele of the apolipoprotein E gene (ApoE), as well as aging increase the risk of Alzheimer's and vascular diseases. Electroencephalogram (EEG) reactivity to hyperventilation (HV) depends on hypocapnia-induced cerebral vasoconstriction, which may be impaired in subjects with subclinical cerebrovascular disease. Quantitative EEG at rest and under 3-minute HV was examined in 125 healthy subjects...
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