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Article

Screening the human prepro-orexin gene in a single-centre narcolepsy cohort.

Sleep medicine - 1 Aug 2007

Quinnell Timothy G, Farooqi I Sadaf, Smith Ian E, Shneerson John M

Abstract excerpt

BACKGROUND AND PURPOSE: Although the orexin system has an established role in narcolepsy, the mechanism of orexin deficiency in human cases is unknown. The strong association with human leukocyte antigen (HLA) DQB1*0602 suggests an autoimmune basis, but supporting evidence is lacking. Although data indicate that HLA status is not the sole genetic factor, only a single case of a functional orexin system mutation...

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Source

Identifiers

PMID: 17576097
DOI: 10.1016/j.sleep.2006.11.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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