Article
HER-2/neu diagnostics in breast cancer.
Breast cancer research : BCR - 1 Jan 2007
Carney Walter P, Leitzel Kim, Ali Suhail, Neumann Rainer, Lipton Allan
Abstract excerpt
HER-2/neu status of the primary breast cancer (PBC) is determined by immunohistochemistry and fluorescent in situ hybridization. Because of a variety of technical factors, however, the PBC may not accurately reflect the metastatic tumor in terms of HER-2/neu status. Recently published guidelines recommend that tumors be defined as HER-2/neu positive if 30% or more of the cells are 3+. Circulating levels of the...
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