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Article

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.

Nature neuroscience - 1 Jul 2007

Agarwal Nitin, Pacher Pal, Tegeder Irmgard, Amaya Fumimasa, Constantin Cristina E, Brenner Gary J, Rubino Tiziana, Michalski Christoph W, Marsicano Giovanni, Monory Krisztina, Mackie Ken, Marian Claudiu, Batkai Sandor, Parolaro Daniela, Fischer Michael J, Reeh Peter, Kunos George, Kress Michaela, Lutz Beat, Woolf Clifford J, Kuner Rohini

Abstract excerpt

Although endocannabinoids constitute one of the first lines of defense against pain, the anatomical locus and the precise receptor mechanisms underlying cannabinergic modulation of pain are uncertain. Clinical exploitation of the system is severely hindered by the cognitive deficits, memory impai...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ganglia, Spinal

Share to Neurons, Afferent

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Share to Peripheral Nervous System

Share to Peripheral Nervous System Diseases

Share to Receptor, Cannabinoid, CB1

Source

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Identifiers

PMID: 17558404
DOI: 10.1038/nn1916
PMCID: PMC2234438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17558404-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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