Article
Rugal hyperplastic gastritis increases the risk of gastric carcinoma, especially diffuse and p53-independent subtypes.
European journal of gastroenterology & hepatology - 1 Jul 2007
Oguri Akihiko, Ohmiya Naoki, Taguchi Ayumu, Itoh Akihiro, Hirooka Yoshiki, Niwa Yasumasa, Maeda Osamu, Ando Takafumi, Goto Hidemi
Abstract excerpt
OBJECTIVES: Infection with Helicobacter pylori has been linked to chronic gastritis with atrophy or hyperrugosity. The development of noncardia gastric carcinoma, especially the intestinal type in Lauren's classification, has been associated with severe atrophic gastritis and p53 mutations. The objective of this study was to determine the association between hyperrugosity and gastric carcinogenesis, including p53...
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