Article
The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance.
British journal of haematology - 1 Jul 2006
Flood Veronica H, Al-Mondhiry Hamid A, Farrell David H
Abstract excerpt
The fibrinogen Aalpha R16C mutation is a common cause of dysfibrinogenaemia and has been previously associated with both bleeding and thrombosis. However, the mechanism underlying the thrombotic phenotype has not yet been elucidated. This report characterises the defect in fibrinolysis seen as a result of the Aalpha R16C mutation. A young patient with dysfibrinogenaemia (fibrinogen Hershey III) was found to be...
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