Article
Single-Stranded RNA Derived from HIV-1 Serves as a Potent Activator of NK Cells
1 Jun 2007
Abstract excerpt
Persistent immune activation is a hallmark of chronic viremic HIV-1 infection. Activation of cells of the innate immune system, such as NK cells, occurs rapidly upon infection, and is sustained throughout the course of the disease. However, the precise underlying mechanism accounting for the persistent HIV-1-induced activation of NK cells is poorly understood. In this study, we assessed the role of uridine-rich...
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