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Article

Substrate and inhibitor specificity of Mycobacterium avium dihydrofolate reductase.

The FEBS journal - 1 Jul 2007

Böck Ronnie A, Soulages Jose L, Barrow William W

Abstract excerpt

Dihydrofolate reductase (EC 1.5.1.3) is a key enzyme in the folate biosynthetic pathway. Information regarding key residues in the dihydrofolate-binding site of Mycobacterium avium dihydrofolate reductase is lacking. On the basis of previous information, Asp31 and Leu32 were selected as residues that are potentially important in interactions with dihydrofolate and antifolates (e.g. trimethoprim), respectively....

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Source

Identifiers

PMID: 17542991
DOI: 10.1111/j.1742-4658.2007.05855.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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