Article
Mitochondrial theory of senescence: respiratory chain protein studies in human skeletal muscle.
Mechanisms of ageing and development - 1 Nov 1991
Byrne E, Trounce I, Dennett X
Abstract excerpt
In view of a previously demonstrated negative correlation between stage III respiratory activity in human mitochondria and increasing age, the relationship between human respiratory chain complex protein content and age was investigated. Quantitative immunoblot studies were carried out using holo complex I, III and IV antibody probes in human skeletal muscle mitochondrial homogenate from patients of varying ages....
Topics
- Aging
- DNA, Mitochondrial
- Humans
- In Vitro Techniques
- Mitochondria, Muscle
- Muscle Proteins
- Mutation
- Oxygen Consumption