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Article

Evaluation of the GenoType MTBDRplus assay for rifampin and isoniazid susceptibility testing of Mycobacterium tuberculosis strains and clinical specimens.

Journal of clinical microbiology - 1 Aug 2007

Hillemann Doris, Rüsch-Gerdes Sabine, Richter Elvira

Abstract excerpt

The new GenoType MTBDRplus assay (Hain Lifescience GmbH, Nehren, Germany) was tested with 125 clinical isolates and directly with 72 smear-positive sputum specimens for its ability to detect rifampin (RMP) and isoniazid (INH) resistance in Mycobacterium tuberculosis complex (MTBC) strains. In total, 106 RMP(r)/INH(r), 10 RMP(s)/INH(r), and 80 RMP(s)/INH(s) MTBC strains were comparatively analyzed with the new and...

Topics

Antitubercular Agents
Bacterial Proteins
Catalase
DNA, Bacterial
DNA-Directed RNA Polymerases
Drug Resistance, Bacterial
Humans
Isoniazid
Microbial Sensitivity Tests
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mycobacterium tuberculosis

Oxidoreductases

Polymerase Chain Reaction

Reagent Kits, Diagnostic

Rifampin

Sensitivity and Specificity

Sequence Analysis, DNA

Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 17537937
DOI: 10.1128/JCM.00521-07
PMCID: PMC1951233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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