Article
Evaluation of the GenoType® MTBDRplus assay and identification of a rare mutation for improving MDR-TB detection.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Apr 2012
Jin J, Zhang Y, Fan X, Diao N, Shao L, Wang F, Hu P, Wang S, Weng X, Zhang W
Abstract excerpt
OBJECTIVE: To assess the new GenoType® MTBDRplus assay for the rapid detection of multidrug-resistant tuberculosis (MDR-TB) in comparison with DNA sequencing to identify drug resistance mutation profiles in China. DESIGN: Using MTBDRplus, drug susceptibility testing (DST) and DNA sequencing, 237 Mycobacterium tuberculosis strains were tested. RESULTS: The sensitivity of MTBDRplus was 75.0% (126/168) for...
Topics
- Antitubercular Agents
- China
- DNA, Bacterial
- Drug Resistance, Multiple, Bacterial
- Genotype
- Humans
- Isoniazid
- Microbial Sensitivity Tests
- Molecular Diagnostic Techniques
- Mutation