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Performance assessment of the GenoType MTBDRplus test and DNA sequencing in detection of multidrug-resistant Mycobacterium tuberculosis.

Journal of clinical microbiology - 1 Aug 2009

Huang Wei-Lun, Chen Huang-Yau, Kuo Yuh-Min, Jou Ruwen

Abstract excerpt

To facilitate the management of multidrug-resistant (MDR) tuberculosis, two nucleic acid sequence-based methods, the GenoType MTBDRplus test and DNA sequencing, were assessed for the rapid detection of drug-resistant Mycobacterium tuberculosis for the first time in the Asia-Pacific region. The performances of these two assays in detecting the presence of rifampin (rifampicin) (RIF) and isoniazid (INH)...

Topics

Asia
Bacterial Proteins
DNA, Bacterial
Drug Resistance, Multiple, Bacterial
Genotype
Humans
Microbial Sensitivity Tests
Molecular Diagnostic Techniques
Mutation, Missense
Mycobacterium tuberculosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sensitivity and Specificity

Sequence Analysis, DNA

Tuberculosis, Multidrug-Resistant

Source

Open in PubMed Open full text

Identifiers

PMID: 19494067
DOI: 10.1128/JCM.02499-08
PMCID: PMC2725636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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