Article
[Novel treatment with oncolytic herpes simplex virus, 'HF10' against breast cancer].
Nihon rinsho. Japanese journal of clinical medicine - 1 May 2004
Kimata Hideto, Teshigahara Osamu, Nishiyama Yukihiro, Nakao Akimasa
Abstract excerpt
An oncolytic herpes simplex virus type 1 mutant, named HF10, has been isolated and evaluated for anti-tumor efficacy in syngeneic immuno-competent mouse models. We have found that the mutant virus can very effectively treat cancer, and that all of survived mice acquire resistance to rechallenge of the tumor cells. Since a number of studies have shown that HF10 is effective and safe for use in localized or...
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