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Article

HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses.

Viruses - 30 Jun 2018

Menotti Laura, Avitabile Elisa, Gatta Valentina, Malatesta Paolo, Petrovic Biljana, Campadelli-Fiume Gabriella

Abstract excerpt

Previously, we engineered oncolytic herpes simplex viruses (o-HSVs) retargeted to the HER2 (epidermal growth factor receptor 2) tumor cell specific receptor by the insertion of a single chain antibody (scFv) to HER2 in gD, gH, or gB. Here, the insertion of scFvs to three additional cancer targets—EGFR (epidermal growth factor receptor), EGFRvIII, and PSMA (prostate specific membrane antigen)—in gD Δ6–38 enabled...

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Identifiers

PMID: 29966356
DOI: 10.3390/v10070352
PMCID: PMC6070899

Genes

EGFR

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