Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis.

doi:10.1128/AAC.00412-07

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Article

Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis.

Antimicrobial agents and chemotherapy - 1 Aug 2007

Taha Muhamed-Kheir, Vázquez Julio A, Hong Eva, Bennett Desiree E, Bertrand Sophie, Bukovski Suzana, Cafferkey Mary T, Carion Françoise, Christensen Jens Jørgen, Diggle Mathew, Edwards Giles, Enríquez Rocío, Fazio Cecilia, Frosch Matthias, Heuberger Sigrid, Hoffmann Steen, Jolley Keith A, Kadlubowski Marcin, Kechrid Amel, Kesanopoulos Konstantinos, Kriz Paula, Lambertsen Lotte, Levenet Ileanna, Musilek Martin, Paragi Metka, Saguer Aouatef, Skoczynska Anna, Stefanelli Paola, Thulin Sara, Tzanakaki Georgina, Unemo Magnus, Vogel Ulrich, Zarantonelli Maria Leticia

Abstract excerpt

Clinical isolates of Neisseria meningitidis with reduced susceptibility to penicillin G (intermediate isolates, Pen(I)) harbor alterations in the penA gene encoding the penicillin binding protein 2 (PBP2). A 402-bp DNA fragment in the 3' half of penA was sequenced from a collection of 1,670 meningococcal clinical isolates from 22 countries that spanned 60 years. Phenotyping, genotyping, and the determination of...

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Identifiers

PMID: 17517841
DOI: 10.1128/AAC.00412-07
PMCID: PMC1932518

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