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CYP2C19*17 protects against metabolic complications of clozapine treatment

30 Jun 2017

Abstract excerpt

OBJECTIVES: Clozapine (CZ) is the most effective drug for managing treatment-resistant schizophrenic disorders. Its use has been limited due to adverse effects, which include weight gain and new-onset diabetes, but the incidence of these varies between patients. METHODS: We investigated 187 Clozapine Clinic patients (of whom 137 consented for genotyping) for the presence of CYP2C19*17 and its association with CZ...

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PMID: 28664816
DOI: 10.1080/15622975.2017.1347712

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