IRAK-M is involved in the pathogenesis of early-onset persistent asthma.

doi:10.1086/518259

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Article

IRAK-M is involved in the pathogenesis of early-onset persistent asthma.

American journal of human genetics - 1 Jun 2007

Balaci Lenuta, Spada Maria Cristina, Olla Nazario, Sole Gabriella, Loddo Laura, Anedda Francesca, Naitza Silvia, Zuncheddu Maria Antonietta, Maschio Andrea, Altea Daniele, Uda Manuela, Pilia Sabrina, Sanna Serena, Masala Marco, Crisponi Laura, Fattori Matilde, Devoto Marcella, Doratiotto Silvia, Rassu Stefania, Mereu Simonetta, Giua Enrico, Cadeddu Natalina Graziella, Atzeni Roberto, Pelosi Umberto, Corrias Adriano, Perra Roberto, Torrazza Pier Luigi, Pirina Pietro, Ginesu Francesco, Marcias Silvano, Schintu Maria Grazia, Del Giacco Gennaro Sergio, Manconi Paolo Emilio, Malerba Giovanni, Bisognin Andrea, Trabetti Elisabetta, Boner Attilio, Pescollderungg Lydia, Pignatti Pier Franco, Schlessinger David, Cao Antonio, Pilia Giuseppe

Abstract excerpt

Asthma is a multifactorial disease influenced by genetic and environmental factors. In the past decade, several loci and >100 genes have been found to be associated with the disease in at least one population. Among these loci, region 12q13-24 has been implicated in asthma etiology in multiple populations, suggesting that it harbors one or more asthma susceptibility genes. We performed linkage and association...

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Identifiers

PMID: 17503328
DOI: 10.1086/518259
PMCID: PMC1867098

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