Article
Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses.
Pharmacogenetics - 1 Apr 2002
Urano Wako, Taniguchi Atsuo, Yamanaka Hisashi, Tanaka Eiichi, Nakajima Hiroshi, Matsuda Yuko, Akama Hideto, Kitamura Yutaka, Kamatani Naoyuki
Abstract excerpt
5,10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme involved in folate metabolism, has two common polymorphisms that affect enzyme activity. The objective of this study was to examine whether there was a correlation between the genotype or haplotype of the MTHFR gene and the efficacy or toxicity of methotrexate (MTX) in the treatment of rheumatoid arthritis. MTX-treated rheumatoid arthritis patients (n...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.