Evaluation of human (genotype 1) and swine (genotype 4)‐ORF2‐based ELISAs for anti‐HEV IgM and IgG detection in an endemic country and search for type 4 human HEV infections

Abstract excerpt

Open reading frame 2 proteins (ORF2) from swine (genotype 4, S-ORF2) and human (genotype 1, H-ORF2) hepatitis E virus (HEV) having 91.4% identity at amino acid level were expressed using baculovirus expression system. Comparison of ELISAs based on the two proteins yielded identical results when sequential serum samples from monkeys and pigs experimentally infected with genotypes 1 and 4 HEV, respectively, were...

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